Betrixaban hydrochloride( PRT054021 hydrochloride )

Catalog No. M19476 CAS No. ——

Betrixaban is a potent selective and orally efficacious factor Xa (fXa) inhibitor (IC50: 1.5 nM).

Purity : >98% (HPLC)

COA

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HNMR

HPLC

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Biological Information

Product Name

Betrixaban hydrochloride
Note

Research use only, not for human use.
Brief Description

Betrixaban is a potent selective and orally efficacious factor Xa (fXa) inhibitor (IC50: 1.5 nM).
Description

Betrixaban is a potent selective and orally efficacious factor Xa (fXa) inhibitor (IC50: 1.5 nM).
In Vitro

——
In Vivo

——
Synonyms

PRT054021 hydrochloride
Pathway

Metabolic Enzyme/Protease
Target

Factor Xa
Recptor

Factor Xa
Research Area

Cardiovascular Disease
Indication

Venous thromboembolism

Chemical Information

CAS Number

——
Formula Weight

488.36
Molecular Formula

C23H23Cl2N5O3
Purity

>98% (HPLC)
Solubility

DMSO: 20 mg/mL (44.26 mM)
SMILES

Cl.COc1ccc(NC(=O)c2ccc(cc2)C(=N)N(C)C)c(c1)C(=O)Nc1ccc(Cl)cn1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Zhang P et al. Discovery of Betrixaban (PRT054021) N-(5-chloropyridin-2-yl)-2-(4-(NN-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide a highly potent selective and orally efficacious factor Xa inhibitor. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2179-85.

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